Document Type : Research Paper
Authors
1
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2
Virology Department, Medical School, Lorestan University of Medical Sciences Khorramabad, Iran
3
Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6815144309, Khorramabad, Lorestan Province, Iran
4
Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
Abstract
Oral anaerobic bacteria cause a wide range of oral diseases. Research results have proven that there is a strong connection between periodontal bacteria and oral anaerobic bacteria with some serious human cancers, oral cavity infections, rheumatoid arthritis, ankylosing spondylitis and even heart disease. Amygdalus scoparia is one of the wild medicinal plants of Iran, which is widely distributed in Lorestan province. Local people of Lorestan use it in traditional medicine to treat diabetes, inflammatory diseases and microbial infections. In this study, the methanolic extract of A. scoparia was tested on several anaerobic bacteria. The results showed that the methanol extract of the A. scoparia can inhibit the growth of Porphyromonas gingivalis, Streptococcus mutans and bacteria at a dilution of 40 mg/ml and the growth of Lactobacillus acidophilus bacteria at a dilution of 25 mg/ml. The minimum inhibition concentration of vancomycin for Porphyromonas gingivalis and Streptococcus mutans is 0.002 mg/ml and for Lactobacillus acidophilus is 0.008 mg/ml. MIC values of metronidazole for Streptococcus mutans, Lactobacillus acidophilus and Porphyromonas gingivalis are 0.008, 0.032 and 0.064 mg/ml, respectively. So, the results demonstrated that the methanolic extract of this plant can be used in the treatment of many diseases related to anaerobic bacteria.
Keywords
Main Subjects
)