Anti-inflammatory Effect of Aqueous Extract of Cassia fistula in Acetic Acid Model of Colitis in Rats

Document Type : Research Paper

Authors

1 Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Pharmacognosy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Herbal Medicines Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran

Abstract

Introduction: Considering the beneficial effects of herbal medicine in comparison with synthetic drugs and also the recommendation of Iranian medical scholars on the use of Cassia fistula in gastrointestinal inflammations, in this study the effect of aqueous extract of Cassia fistula fruit on the histopathological improvement of ulcerative colitis was evaluated in rats.
Methods: In this study, 30 rats with a weight range of 250-300 g and about 2 months were used. Ulcerative colitis was induced by acetic acid in rats, then the animals were treated orally with normal saline, sulfasalazine (360 mg/kg), or aqueous extract of Cassia fistula (600 and 800 mg/kg) once daily for 5 days. The animals were then sacrificed and their colons were evaluated macroscopically, histopathologically, and for myeloperoxidase (MPO) activity and weight.
Results & conclusion: The severity and extent of colonic inflammation in animals receiving 400 and 800 mg/ml of Cassia fistula extract showed a significant decrease compared to those receiving normal saline (P <0.05). A decrease in colon weight was observed in the group of animals receiving a concentration of 800 mg/ml of the extract. Cassia fistula aqueous extract did not show any effect in reducing the activity of the MPO enzyme.

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Journal of Medicinal plants and By-product

Articles in Press, Accepted Manuscript
Available Online from 04 January 2024

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