Iranian Medicinal Plants Society Journal of Medicinal plants and By-products 2322-1399 13 3 2024 09 01 Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer 605 613 129806 10.22034/jmpb.2023.362108.1548 EN Bakhan Bahadeen Aref Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran Sajad Fakhri Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran Mohammad Reza Morovati Persian Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran Maryam Ghanbari-Movahed Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran Ehsan Mohammadi Noori Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran Shahram Miraghaei Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Science, Kermanshah, Iran Mohammad Hosein Farzaei Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran Journal Article 2022 04 26 There is usually a connection between the secretion of stomach acid and stomach ulcers, but today the main cause of these ulcers is considered to be the presence and proliferation of <em>Helicobacter pylori</em> bacteria, which causes peptic ulcers in various ways, including damage to the protective layer. Therefore, the aim of this study is to investigate the protective effect of the aqueous and hydroalcoholic extracts of <em>Plantago major</em> L. leaves on gastric ulcers induced by ethanol in rats. First, 36 adult male Wistar rats were selected and divided into 9 groups including famotidine and control groups, healthy groups, and protective groups that received the aqueous and hydroalcoholic extracts of the leaves of the <em>P. major</em>. After preparing and checking the obtained results, quantitative data was evaluated with a one-way analysis of variance and Tukey's post hoc test using SPSS software. The macroscopic examination results showed that in both groups receiving aqueous and hydroalcoholic extracts of the <em>P. major</em> plant, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. The general results of the present study showed that in both groups receiving the aqueous and hydroalcoholic extracts of the plant leaves, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. In conclusion, our findings indicated that this extract is a potential agent that can be used for the treatment of peptic ulcers and gastric tissue wounds. https://jmpb.areeo.ac.ir/article_129806_1920963f07fe30477db056bcb573cb40.pdf