Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago Major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer

Document Type : Research Paper

Authors

1 Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran

2 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran

3 Persian Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran

4 Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Science, Kermanshah, Iran

Abstract

There is usually a connection between the secretion of stomach acid and stomach ulcers, but today the main cause of these ulcers is considered to be the presence and proliferation of Helicobacter pylori bacteria, which causes peptic ulcers in various ways, including damage to the protective layer. Therefore, the aim of this study is to investigate the protective effect of the aqueous and hydroalcoholic extracts of Plantago major leaves on gastric ulcers induced by ethanol in rats. First, 36 adult male Wistar rats were selected and divided into 9 groups including famotidine and control groups, healthy groups, and protective groups that received the aqueous and hydroalcoholic extracts of the leaves of the Plantago major. After preparing and checking the obtained results, quantitative data was evaluated with a one-way analysis of variance and Tukey's post hoc test using SPSS software. The macroscopic examination results showed that in both groups receiving aqueous and hydroalcoholic extracts of the Plantago major plant, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. The general results of the present study showed that in both groups receiving the aqueous and hydroalcoholic extracts of the plant leaves, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. In conclusion, our findings indicated that this extract is a potential agent that can be used for the treatment of peptic ulcers and gastric tissue wounds.

Keywords

Main Subjects

Journal of Medicinal plants and By-product

Articles in Press, Accepted Manuscript
Available Online from 08 September 2023

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