Medicinal Plants Used for Neonatal Jaundice in Shahrekord: An Ethnobotanical Study


1 Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran

2 Community Medicine Department, Lorestan University of Medical Science, Khorramabad, Iran

3 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

4 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

5 Department of Pediatrics, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


Jaundice begins in the infants from the very early days of birth; the symptoms usually appear with yellow skin and sometimes eyes, jaundice first involves only the face, but it also affects the chest, abdomen, legs, and the soles of the feet and the lower limbs.  In this ethnobotanical study, attempt was made to identify medicinal plants used in the herbal medicine of Shahrekord region to treat neonatal jaundice. This cross-sectional study was performed by collecting data through an ethnobotanical knowledge questionnaire from 21 April 2016 to 19 February 2017, through face-to-face interview with 29 traditional therapists. The results of the questionnaire were distributed among traditional therapists and information was obtained.  The results showed that in the ethnobotany of Shahrekord, Descurainia sophia (L.) Webb ex Prantl, Cichorium intybus L., Alyssum spp. Stead. Ex Boiss., Fumaria spp., Adianthum capillus-veneris L., Astragalus adscendens (Boiss. & Hausskn.) Podlech, Alcea spp., Vinifera Spp. and Rheum ribes L. are used as anti-neonatal jaundice medicinal plants. The results shows that leaf (41%) is the most commonly used plant organ for jaundice in the studied region. According to the results of our ethnobotanical study, the plants reported in this study are traditionally used to prevent neonatal jaundice, and it is necessary to prove these effects in clinical and pharmacological studies.


1. Piazza AJ, Stoll BJ. Digestive system disorder. In: kliegman, Behrman, Jenson .Nelson text book of pediatrics. 18th ed. Philadelphia: saunders. 2007;753-66.

2. Jasprova J., Dal Ben M., Vianello E., Goncharova I., Urbanova M., Vyroubalova K., et al. The biological effects of bilirubin photoisomers. PLoS ONE 11:e0148126. 2016.

3. Ullah S., Rahman K., Hedayati M. Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures and treatments: a narrative review article. Iran. J. Public Health45. 2016;558.

4. Constantin T. Jaundice obstructive syndrome. Curr Health Sci J. 2011; 37:96–100. 

5. Ronald J. Wong Glenn H. DeSandre Eric Sibley David K. Stevenson. Neonatal jaundice and liver disease. In: Fanarroff AA, Martin RJ. Neonatal –Perinatal medicine. 8th ed. Philadelphia: Mosby.  2006;1419- 1466.

6. Ogunfowora OB, Daniel OJ. Neonatal jaundice and its management: knowledge, attitude and practice of community health workers in Nigeria.J BMC Public health. 2006 Jan27;6:19.

7. Ghaffari V, Vahid Shani K, Taleshi BA. Knowledge and attitude about neonatal ICTR among mother in Sari. Journal of Mazandaran University of Medical Sciences. 2006;52:92-97.

8. Steffensrud S. Tin-metalloporphyrins: an answer to neonatal jaundice? Neonatal Netw. 1998;17:11-17.

9. Kappas A, Drummond GS, Henschke C, Valaes T. Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics. 1995;95:468-474.

10. Dennery PA. Pharmacological interventions for the treatment of neonatal jaundice. Semin Neonatol. 2002;7:111-119.

11. Bourget P, Broise I, Quinquis-Desmaris V, Gabilan JC. [Pharmacokinetics of clofibrate in jaundiced newborn infants at term]. Arch Pediatr. 1995;2:722-728.

12. Gourley GR, Li Z, Kreamer BL, Kosorok MR. A controlled, randomized, double-blind trial of prophylaxis against jaundice among breastfed newborns. Pediatrics. 2005;116:385-391.

13. Davis DR, Yeary RA. Activated charcoal as an adjunct to phototherapy for neonatal jaundice. Dev Pharmacol Ther. 1987;10:12-20.

14. Mohammadzadeh A, Farhat ASh, Iranpour R. Effect of clofibrate in jaundiced term newborns. Indian J Pediatr. 2005;72:123-126.

15. Thomas CR. Routine phenobarbital for prevention of neonatal hyperbilirubinemia. Obstet Gynecol. 1976;47:304-308.

16. Johnson LH, Bhutani VK, Brown AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr. 2002;140:396-403.

17. Kligman  RM. Anemia in the the newborn infant. In: Behrman, Kliegman, Jenson. Textbook of Pediatrics. 17th ed. Philadelphia, Saunders. 2004:599-608.

18. Kappas A, Drummond GS, Henschke C, Valaes T. Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics. 1995;95:468-474.

19. Lazar MA. East meets West: an herbal tea finds a receptor. J Clin Invest. 2004;113:23-25.

20. Asadi, S.Y., Parsaei, P., Karimi, K., Rafieian-Kopaei, M. Effect of ethanolic extract of green tea (Camellia sinensis) on intra-abdominal adhesions in rats. Journal of Zanjan University of Medical Sciences and Health Services. 2017;21:86-96.

21. Karimi M, Yazdan Asadi S, Parsaei P, Rafieian-Kopaei M, Ghaheri H, Ezzati S.The Effect of Ethanol Extract of Rose (Rosa damascena) on Intra-abdominal Adhesions after Laparotomy in Rats. Wounds. 2016;28:167-174.

22. Froushani SMA, Zarei L, Ghaleh HEG, Motlagh BM. Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects. Avicenna Journal of Phytomedicine. 2016;6:526-534.

23. Abbasi N, Azizi Jalilian F, Abdi M, Saifmanesh M. A comparative study of the antimicrobial effect of Scrophularia striata Boiss. Extract and selective antibiotics against Staphylococcus aureus and Pesudomonas aeruginosa. Journal of Medicinal Plants. 2007;6:10-18+69.

24. Karimi, M., Parsaei, P., Shafiei-Alavijeh, S., Rafieian-Kopaei, M., Asadi, S.Y. Effect of silymarin alcoholic extract on surgery-induced intraperitoneal adhesion in rats. Surgical Practice. 2016.

25. Bahmani, M., Khaksarian, M., Rafieian-Kopaei, M., Abbasi, N. Overview of the therapeutic effects of origanum vulgare and hypericum perforatum based on Iran’s ethnopharmacological documents. Journal of Clinical and Diagnostic Research. 2018;12:1-4.  

26. Shokri Z, Khoshbin M, Koohpayeh A, Abbasi N, Bahmani F,  Rafieian-Kopaei, M, Beyranvand F. Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants. International Journal of Green Pharmacy. 2018;12:473-482.  

27. Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, Asadollahi K. Protective effects of smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: Involvement of benzodiazepine and opioid antagonists. Journal of Biological Regulators and Homeostatic Agents. 2017;31:683-689.  

28. Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM.The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus. Journal of Microbiology. 2018;56:128-137

29. Karimi, Mehrdad. and Mardani, Mahnaz. and Parsaei, Pouya. An overview of the effectiveness of the most important native medicinal plants of iran on hemorrhoid based on iranian traditional medicine textbooks. Journal of Global Pharma Technology. 2016;8:24-26.

30. Bahmani M, Taherikalani M, Khaksarian M, Rafieian-Kopaei M, Ashrafi B, Nazer M et al., The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci OA. 2019 Jan 31;5:FSO371. doi: 10.4155/fsoa-2018-0096. eCollection 2019 Mar.

31. Lavasanijou MR, Sohrabi HR, Karimi M, Ashjazade MA, Salajeghe M, Farzineejadizadeh H, Parsaei P, Elmamooz A.Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats. Wounds. 2016;28:369-375.

32. Bahmani, M., Mozaffari Nejad, A. S., Shah, N. A., Shah, S. A., Rafieian-Kopaei, M., & Mahmoodnia, L. Survey on ethnobotanical uses of anti-cancer herbs in Southern region of Ilam, West Iran. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale. 2017;90.

33. Delfani, S., Bahmani, M., Mohammadrezaei- Khorramabadi, R., Rafieian-Kopaei, M. Phytotherapy in Streptococcus agalactiae: An overview of the medicinal plants effective against Streptococcus agalactiae. J Clin Diagn Res. 2017 Jun;11:DE01–DE02.

34. Rafieian-kopaei, M., Shakiba, A., Sedighi, M., Bahmani, M. The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice . J Evid Based Complementary Altern Med. 2017;22:892-896. 

35. Asadi N, Husseini SD, Tohidian MT, Abdali N, Mimandipoure A, Rafieian-Kopaei M, Bahmani M. Performance of Broilers Supplemented With Peppermint ( Mentha piperita L.) Powder. J Evid Based Complementary Altern Med. 2017;22:703-706.

36. Alizadeh M, Safarzadeh A, Bahmani M, Beyranvand F, Mohammadi M, Azarbaijani K, Rafieian-Kopaei M, Abbaszadeh S. Brucellosis: Pathophysiology and new promising treatments with medicinal plants and natural antioxidants. Asian Pac J Trop Med. 2018;11:597-608.

37. Fok TF. Neonatal jaundice-traditional Chinese medicine approach. Journal of Perinatology.  2001;21:98–110.

38. Nabavi Zadeh SH, Safari M, Khoshnevisan F. The effect of herbal drugs on neonatal Jaundice. Iranian Journal of Pediatrics. 2005;15:138-133.

39. Raeisi R, Heidari-Soureshjani S, Asadi-Samani M and Luther T: A systematic review of phytotherapies for newborn jaundice in Iran. Int J Pharm Sci Res. 2017;8: 1953-1958. doi: 10.13040/IJPSR.0975-8232.8(5).1953-58.

40.  Amiri MS, Joharchi MR, TaghavizadehYazdi ME. Ethno-Medicinal Plants Used to Cure Jaundice by Traditional Healers of Mashhad, Iran. Iran J Pharm Res. 2014;13:157–162.

41. Ahmadipour SH, Ahmadipour S, Mohsenzadeh A and Hassanzadazar H. Neonatal jaundice treatment with Iranian native medicinal plants: Cotoneaster persicus, most important medicinal plant affecting on neonatal jaundice. Der Pharmacia Lettre. 2015;7:313-315.

42. Ghasemi Pirbalouti A, Momeni M and Bahmani M. ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS USED BY KURD TRIBE IN DEHLORAN AND ABDANAN DISTRICTS, ILAM PROVINCE, IRAN. Afr J Tradit Complement Altern Med. 2013;10:368-385.

43. Safa O, Soltanipoor MA, Rastegar S, Kazemi M, Nourbakhsh Dehkordi KH, Ghannadi A. An ethnobotanical survey on hormozgan province, Iran. Avicenna Journal of Phytomedicine. 2013;3:64-81.

44. Razmjoue D, Zarei Z, Armand R. Ethnobotanical Study (Identification, Medical Properties and How to Use) of some Medicinal Plants of Behbahan city of Khuzestan Province, Iran. J Medicinal Plants. 2017;16:11:33-49.

45. Nawal H. Mohamed1 and Atta E. Mahrous. Chemical Constituents of  Descurainia sophia L. and its Biological Activity. Rec. Nat. Prod. 2009;3:58-67.

46. Marzia Innocenti, Sandra Gallori, Catia Giaccherini, Francesca Ieri, Franco F. Vincieri, Nadia Mulinacci. Evaluation of the Phenolic Content in the Aerial Parts of Different Varieties of Cichorium intybus L. J. Agric. Food Chem. 2005;53:6497-6502.

47. Richard H. F. Manske. THE ALKALOIDS OF FUMARIACEOUS PLANTS: XVIII. FUMARIA OFFICINALIS L. Canadian Journal of Research. 1938;16b:438-444.

48. Zedan Z.IbraheimAmany S.AhmedYaser G.Gouda. Phytochemical and biological studies of Adiantum capillus-veneris L. Saudi Pharmaceutical Journal. 2011;19:65-74.

49. Forough Naemi, Gholamreza Asghari, Hossein Yousofi, and Hossein Ali Yousefi. Chemical composition of essential oil and anti trichomonas activity of leaf, stem, and flower of Rheum ribes L. extracts. Avicenna J Phytomed. 2014;4:191–199.

50. Mir Heydar H Herbal Education, Plant Use in the Prevention and Treatment of Diseases, Office of the Publishing of Islamic Culture. 1996;3:173 and 175.

51. Iranian Herbal Pharmacopoea Scientific Committee. "Iranian Herbal Pharmacopoea". 1st ed. Tehran: Iranian ministry of health publications. 2002;578-87.

52. Singh M, Singh N, Khare PB, Rawat AKS. Antimicrobial activity of some important Adiantum species used traditionally in indigenous systems of medicine. J. Ethnopharmacol. 2008;115:327 -32 9.

53. Yu H., Zhao X., Xu G., Wang S.E., Effect of grape seed extracts on blood lipids in rabbits model with hyperlipidemia, Wei Sheng Yan Jiu. 2002;31:114-116.

54. Giasudin Jazaieri. Zaban Khorakiha. 1983;1:39- 41.