Comparative and Combined Effects of Echium amoenum and Cichorium intybus Extracts on the Live of Wista Rats

Document Type : Research Paper

Authors

1 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

2 Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Abstract

The study is aimed to evaluate the effects of Echium amoenum and Cichorium intybus extracts on the liver of Wistar rats. Ninty rats were divided into 15 groups. Group 1 received physiological serum, groups 2, 3, 4 and 5 40 mg/Kg, 6, 7, 8 and 9, 400 mg/Kg, 10, 11, 12 and 13, 1000 mg/Kg aqueous and ethanolic extract of C.intybus and E. amoenum, group 14 and 15, 400 mg/Kg combined aqueous and ethanolic extracts. Blood samples were collected to assay AST, ALT, ALP, GGT, MDA, total protein and bilirubin levels. The effect of different concentrations of aqueous extracts of chicory and echium on AST, ALT, ALP, GGT and bilirubin levels is the same. Concentrations of 40 to 1000 mg/kg of chicory ethanol extract had different effects on AST, ALP and bilirubin, but in the case of ALT, the differences were between 40 and 400 mg/kg. The flavonoid and anthocyanin contents were the highest in ethanolic extract of echium. Antioxidant activity and total phenols content in ethanolic extract were higher than aqueous extract. The use of aqueous extract of chicory in high concentrations did not harm the liver. Ethanolic extracts of both plants at 1000 mg/Kg will damage the liver. The ethanolic extracts of both plants contain many phenolic compounds that increase the inhibition of free radicals in this extract.

Keywords

References

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Journal of Medicinal plants and By-product
Volume 12, Issue 4
December 2023
Pages 495-503

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