Essential Oils of Nepeta kurdica and Nepeta Chionophila from Iran as two Sources of Nepetalactone Isomers

Document Type : Research Paper

Authors

Research Institute of Forests and Rangelands, Agricultural Research Education and Extension Organization (AREEO), Tehran, Iran

Abstract

This research aimed to identify the volatile compounds of essential oils found in the aerial parts of two Nepeta species (N. kurdica Hausskn. & Bornm., and N. chionophila Boiss. & Hausskn.). This is the first phytochemical investigation of these two Nepeta species. The essential oils were obtained by hydro-distillation and analyzed by a combination of capillary gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS). Nineteen compounds accounting for 90.8% of N. kurdica oil were identified, while there were fifteen volatile components corresponding to 95.1% in N. chionophila oil. Nepetalactone isomers make up 64.2% of N. kurdica and 90.5% of N. chionophila oils. The main component of N. kurdica oil was 4aa-7a-7aa-nepeta lactone (57.7%), while 4aα-7a-7ab-nepeta lactone (71.8%) and 4aa-7a-7aa-nepeta lactone (15.9%) were the major constituents of N. chionophila oil. So, the essential oils of N. chionophila (endemic) and N. kurdica (native) can be used the same as catnip (N. cataria) oil that is used for antimicrobial, repellent and insecticide effect, as a fortifier, a disinfectant and a cure against cold.

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References

  1. Jamzad Z., Ingrouille M., Simmonds M. Three new species of Nepeta (Lamiaceae) from Iran. Taxon. 2003; 52: 93-98.
  2. Mozaffarian V. A Dictionary of Iranian Plant Name. Farhang Moaser, Tehran, Iran. 2013.
  3. Zargari A. Medicinal Plants. Tehran University Publications. Tehran, Iran. 1990; Vol 4: 4th ed.
  4. Javidnia K., Miri M., Safavi F., Azarpira A., Shafiee A. Composition of the essential oil of Nepeta persica Boiss. from Iran. Flavour Fragr J. 2002; 17: 20-22.
  5. Formisano C., Rigano D., Senatore F. Chemical constituents and biological activities of Nepeta species. Chem Biodivers. 2011; 8:1783-1818.
  6. Süntar, I., Nabavi, S.M., Barreca, D., Fischer, N. and Efferth, T., Pharmacological and chemical features of Nepeta L. genus: Its importance as a therapeutic agent. Phyto Res. 2017; 5946, 1-14.
  7. Nestorović, J., Mišić, D., Šiler, B., Soković, M., Glamočlija, J., Ćirić, A., Maksimović, V. and Grubišić, D., Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity. Fitoterapia. 2010; 81(6): 621-626.
  8. Asgarpanah J, Sarabian S, Ziarati P. Essential oil of Nepeta genus (Lamiaceae) from Iran: a review. J Essent Oil Res. 2013; 26(1): 1-12.
  9. Sefidkon F., Jamzad Z., Mirza M. Chemical composition of the essential oil of five Iranian Nepeta species (N. crispa, N. mahanensis, N. ispahanica, N. eremophila and N. rivularis). Flavour Fragr J. 2006; 21: 764–767.
  10. Sefidkon F., Akbarinia A. Essential oil composition of Nepeta pogonosperma Jamzad & Assadi from Iran. J Essent Oil Res. 2003; 15: 327-328.
  11. Sefidkon F., Shaabani A. Essential oil composition of Nepeta meyeri Benth. from Iran, Flavour Fragr J. 2004; 19: 236-236.
  12. Dabiri M., Sefidkon F. Chemical composition of Nepeta crassifolia Boiss. & Buhse oil from Iran. Flavour Fragr J. 2003a; 18: 225-227.
  13. Matloubi Moghadam F., Hosseini M. Composition of the essential oil from Nepeta crassifolia Boiss. & Buhse. Flavour Fragr J. 1996; 11: 113-115.
  14. Dabiri M., Sefidkon F. Chemical composition of the essential oil of Nepeta racemosa Lam. from Iran. Flavour Fragr J. 2003b; 18: 157-158.
  15. Hadi N., Sefidkon F., Shojaeiyan A., Jafari A.A. Essential oil diversity of 21 populations from Iranian endemic species Nepeta kotschyi Boiss. Iran J Med Arom Plants. 2016; 32(2): 189-202.
  16. Ghannadi A., Aghazari F., Mehrabani M., Mohagheghzadeh A., Mehregan I. Quantity and composition of the SDE prepared essential oil of Nepeta macrosiphon Boiss., Iran J Pharma Res. 2003; 103-105.
  17. Sefidkon F., Dabiri M., Alamshahi A. Analysis of the essential oil of Nepeta fissa C. A. May from Iran. Flavour Fragr J. 2001; 17: 89-90.
  18. Hadian J., Sonboli A., Nejad Ebrahimi S., Mirjalili, M.H., Essential oil composition of Nepeta satureioides from Iran. Chem Nat Compd. 2006; 42: 175-177.
  19. Sajjadi S.E., Ghassemi N., Marini M. Chemical Constituents of the Essential Oil of Nepeta prostrata from Iran. J Essen Oil, Bearing Plants. 2012; 15(4): 557-560.
  20. Shakeri A., Khakdan F., Soheili V., Sahebkar A., Rassam G., Asili J. Chemical composition, antibacterial activity, and cytotoxicity of essential oil from Nepeta ucrainica L. spp. Kopetdaghensis. Ind Crops Prod. 2014; 58: 315-321.
  21. Sefidkon F. Essential oil composition of Nepeta glomerulosa Boiss. from Iran. J. Essent Oil Res. 2001; 13: 422-423.
  22. Jalili A., Jamzad Z. Red Data Book of Iran. Research Institute of Forests and Rangelands, Tehran, Iran. 1999.
  23. Adams R.P. Identification of Essential Oil Components by Gas Chromatography/Quadropole Mass Spectroscopy, Allurd Publishing Corp. Carol Stream, USA. 2017.
  24. Shibamoto T. Retention Indices in Essential Oil Analysis, In: Capillary Gas Chromatography in Essential Oil Analysis. Edits., P. Sandra and C. Bicchi, Huethig, Verlag, New York. 1987.
  25. Davies B.W. Gas chromatographic retention indices of monoterpenes and sesquiterpenes on methyl silicone and Carbowax 20M phases. J Chromatogr. 1990; 503: 1-24.
  26. Lichman B.R., Godden G.T., Hamilton J.P., Palmer L., Kamileen M.O., Zhao D., Vaillancourt B., Wood J.C., Sun M., Kinser T.J., Henry L.K., Lopez C.R., Dudareva N., Soltis D.E., Soltis P.S., Buell C.R., O’Connor S.E. The evolutionary origins of the cat attractant nepetalactone in catnip. Sci Adv. 2020; 6(20): eaba0721.
  27. Birkett M.A., Hassanali A., Hoglund S., Pettersson J., Pickett J.A. Repellent activity of catmint, Nepeta cataria, and iridoid nepetalactone isomers against Afro-tropical mosquitoes, ixodid ticks and red poultry mites. Phytochem. 2011; 72(1): 109-114.
  28. Khan M.A., Jones I., Loza-Reyes E., Cameron M.M., Pickett J.A., Birkett M.A. Interference in foraging behaviour of European and American house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae (Acari: Pyroglyphidae) by catmint, Nepeta cataria (Lamiaceae). Exp Appl Acarol. 2012; 57(1): 5-74.
  29. Zhu J.J., Berkebile D.R., Dunlap C.A., Zhang A., Boxler D., Tangtrakulwanich K., Behle R.W., Baxendale F., Brewer G. Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent. Med Vet Entomol. 2011; 26(2): 131-8.
  30. Reichert W., Ejercito J., Guda T., Dong X., Wu Q., Ray A., Simon J.E. Repellency Assessment of Nepeta cataria Essential Oils and Isolated Nepetalactones on Aedes aegypti. Sci Rep. 2019; 9(1): 1524.
  31. Sajjadi S.E., Eskandari B. Chemical constituents of the essential oil of Nepeta oxyodonta. Chem Nat Compd. 2005; 41: 175-177.
  32. Sajjadi S.E., Ghassemi N. Volatile constituents of Nepeta glomerulosa Boiss. subsp. carmanica. Flavour Fragr J. 1999; 14: 265-267.
  33. Ghannadi A., Aghazari F., Mehrabani M., Mohagheghzadeh A., Mehregan I. Quantity and composition of the SDE prepared essential oil of Nepeta macrosiphon Boiss. Iran J Pharm Res. 2003; 2: 103-105.
  34. Mehrabani M., Asadipour A., Saber Amoli S. Chemical constituents of the essential oil of Nepeta depauperata Benth. from Iran. Daru. 2004; 12: 98-100.
  35. Javidnia K, Miri R, Mehregan I, Sadeghpour H. Volatile constituents of the essential oil of Nepeta ucrainica L. ssp. kopetdaghensis from Iran. Flavour Fragr J. 2005; 20: 219-221.
  36. Sonboli A., Salehi P., Allahyari L. Essential oil composition of Nepeta involucrata from Iran. Chem Nat Compd. 2005; 41: 683-685.
  37. Sefidkon F., Jamzad Z. Essential oil composition of four Iranian Nepeta species (N. cephalotes, N. bornmuelleri, N. mirzayanii and N. bracteata). J Essent Oil Res. 2007; 19: 262-265.
  38. Mojab F., Nickavar B., Hooshdar Tehrani H. Essential oil analysis of Nepeta crispa and N. menthoides from Iran. Iran J Pharm Sci. 2009; 5: 43-46.
  39. Akhgar M.R., Moradalizadeh M. Chemical composition of the essential oils from stems, flowers and leaves of Nepeta schiraziana Boiss. Iran J. Med. Arom. Plants. 2012; 28: 28-34.
  40. Farjam M.H. Antibacterial activity and composition of essential oil of Nepeta pungens Benth. from Iran. J. Appl Pharm Sci. 2012; 02(04): 103-105.
Journal of Medicinal plants and By-Products
Volume 13, Issue 3
September 2024
Pages 599-604

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