Phytochemical Screening and Wound Healing Activity of the Essential Oil of Pistacia khinjuk

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Document Type : Research Paper

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University of Basra, College of Pharmacy, Department of Pharmacognosy and Medicinal Plants

Abstract

The tree or shrub Pistacia khinjuk is a member of the Anarcadiaceae family and is indigenous to Iraq. It is a significant medicinal plant with several pharmacological qualities used in traditional and contemporary medicine, including anti-inflammatory, antioxidant, and antihyperlipidemic effects. The current study investigated the chemical components of the essential oil of the fresh fruits of P. khinjuk growing in Sulaymaniah, northern Iraq, considering the body of research on the makeup of the oil that is extracted from this plant's fruits. Fresh fruits from P. khinjuk plants were extracted for three hours using a reflux system, and the constituents were assessed by gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). The findings of the qualitative and quantitative examination of the essential oil are reported, together with the chemical ingredients discovered by HPLC and GC/MS. GC/MS found 21 chemicals in total, with n-hexadecanoic acid (palmitic acid) being the most abundant (46.44%). HPLC identified 5 compounds, including oleic acid as the most abundant. Furthermore, in vitro wound healing assays demonstrated that a concentration of 200 µg/mL of P. khinjuk fruit oil extract resulted in near-complete scratch closure of fibroblast cultures after 72 hours, significantly accelerating wound closure compared to untreated controls. This study represents the first investigation into the wound-healing properties of oil extracted from the fruits of P. khinjuk, highlighting its potential as a novel therapeutic agent.

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Journal of Medicinal plants and By-Products

Articles in Press, Accepted Manuscript
Available Online from 27 February 2025

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