Efficacy of Ferula gummosa Essential Oil in an Anti-Acne Cream: Evaluation of Antibacterial Activity, Sebum Reduction, and Sensory Properties

Articles in Press

Document Type : Research Paper

Authors

1 Department of Horticultural Science and Agronomy, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Research Institute of Forests and Rangelands, Agricultural Research Education and Extension Organization (AREEO), Tehran, Iran

3 Department of Horticulture Science and Agronomy, Science and Research branch of Islamic Azad University, Tehran, Iran

Abstract

Acne vulgaris is a prevalent skin condition affecting adolescents and young adults, with conventional treatments often leading to undesirable side effects. This study developed the formulation of an anti-acne cream based on Ferula gummosa essential oil and evaluated its physicochemical properties, antibacterial efficacy, and effects on sebum production. The formulated cream demonstrated favorable physicochemical properties, making it suitable for skin application. It exhibited strong antibacterial activity against both Propionibacterium acnes and Staphylococcus epidermidis. Significant reductions in sebum levels were observed in all areas of the face studied at the end of the trial. Participants rated the cream highly on several quality dimensions, although improvements in fragrance were suggested. The anti-acne cream containing galbanum essential oil shows significant potential in the treatment of acne vulgaris, combining effective sebum reduction and antibacterial activity with favorable user acceptability. This study supports further development and clinical testing of F. gummosa based formulations as a natural and effective treatment option for acne.

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Journal of Medicinal plants and By-Products

Articles in Press, Accepted Manuscript
Available Online from 18 April 2025

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