Efficacy of Ferula gummosa Essential Oil in an Anti-Acne Cream: Evaluation of Antibacterial Activity, Sebum Reduction, and Sensory Properties

Document Type : Research Paper

Authors

1 Department of Horticultural Science and Agronomy, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Research Institute of Forests and Rangelands, Agricultural Research Education and Extension Organization (AREEO), Tehran, Iran

3 Department of Horticulture Science and Agronomy, Science and Research branch of Islamic Azad University, Tehran, Iran

Abstract

Acne vulgaris is a prevalent skin condition affecting adolescents and young adults, with conventional treatments often leading to undesirable side effects. This study developed the formulation of an anti-acne cream based on Ferula gummosa essential oil and evaluated its physicochemical properties, antibacterial efficacy, and effects on sebum production. The formulated cream demonstrated favorable physicochemical properties, making it suitable for skin application. It exhibited strong antibacterial activity against both Propionibacterium acnes and Staphylococcus epidermidis. Significant reductions in sebum levels were observed in all areas of the face studied at the end of the trial. Participants rated the cream highly on several quality dimensions, although improvements in fragrance were suggested. The anti-acne cream containing galbanum essential oil shows significant potential in the treatment of acne vulgaris, combining effective sebum reduction and antibacterial activity with favorable user acceptability. This study supports further development and clinical testing of F. gummosa based formulations as a natural and effective treatment option for acne.

Keywords

Main Subjects

References

  1. Zaenglein A.L., Pathy A.L., Schlosser B.J., Alikhan A., Baldwin H.E., Berson D.S., Bowe W.P., Graber E.M., Harper J.C., Kang S., Keri J.E., Leyden J.J., Reynolds R.V., Silverberg N.B., Stein Gold L.F., Tollefson M.M., Weiss J.S., Dolan N.C., Sagan A.A., Stern M., Boyer K.M., Bhushan R. Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology. 2016;74(5):945-973.e33.
  2. Cong T.X., Hao D., Wen X., Li X.H., He G., Jiang X. From pathogenesis of acne vulgaris to anti-acne agents. Archives of Dermatological Research. 2019;311(5):337-349.
  3. Oge L.K., Broussard A., Marshall M.D. Acne vulgaris: Diagnosis and treatment. American Family Physician. 2019;100(8):475-484.
  4. Mozaffarian V. A dictionary of Iranian plant names: Latin-English-Persian: Farhang Mo'aser. 1996.
  5. Mozaffarian V. The family of Umbelliferae. Iran- Keys and Distribution. Research Institute of Forests and Rangelands Press, Tehran, 1983, pp. 114-116.
  6. Panahi M., Rezaee M.B., Jaimand K. A review of phytochemistry and phylogeny that aid bio-prospecting in the traditional medicinal plant genus Ferula L.(Apiaceae) in Iran. Journal of Medicinal plants and By-Products. 2020;9(2):133-148.
  7. Mahboubi M. Ferula gummosa, a traditional medicine with novel applications. Journal of Dietary Supplements. 2016;13(6):700-718.
  8. Eftekhar F., Yousefzadi M., Borhani K. Antibacterial activity of the essential oil from Ferula gummosa seed. Fitoterapia. 2004;75(7):758-759.
  9. Fatemikia S., Abbasipour H., Saeedizadeh A. Phytochemical and acaricidal study of the galbanum, Ferula gummosa Boiss. (Apiaceae) essential oil against tetranychus urticae koch (tetranychidae). Journal of Essential Oil Bearing Plants. 2017;20(1):185-195.
  10. Jalili-Nik M., Soukhtanloo M., Javanshir S., Jahani Yazdi A., Esmaeilizadeh M., Jafarian A.H., Ghorbani A. Effects of ethanolic extract of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes. Research in Pharmaceutical Sciences. 2019;14(2):138-145.
  11. Mofasseri M., Tofighi Z., Pirali Hamedani M., Hadjiakhoondi A., Tavakoli S., Moein Z., Baharipour Z. Remarkable variation in phytochemicals of Ferula gummosa Bioss. essential oils collected from different parts of Iran. Research Journal of Pharmacognosy. 2022;9(4):29-38.
  12. Vaez Shahrestani A., Azimi R., Abdousi V., Mirza M., Ghanbari Jahromi M. Evaluation of the physical and chemical properties of the essential oil obtained from the oleo-gum-resin of two populations of Ferula gummosa from Isfahan and Fars provinces. Eco-phytochemical Journal of Medicinal Plants. 2024;12(1):103-119.
  13. Moon S.H., Roh H.S., Kim Y.H., Kim J.E., Ko J.Y., Ro Y.S. Antibiotic resistance of microbial strains isolated from korean acne patients. The Journal of Dermatology. 2012;39(10):833-837.
  14. Mohammadhosseini M., Venditti A., Sarker S.D., Nahar L., Akbarzadeh A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A Review. Industrial Crops and Products. 2019;129:350-394.
  15. Asnaashari S., Kazemnezhad M., Masoud F., Javadzadeh Y. An overview on the anti-acne properties of herbal essential oils. Journal of Herbal Medicine. 2023;38:100642.
  16. ISO 14716:1998(E). Oil of galbanum (Ferula galbaniflua Boiss. et Buhse).
  17. Jalali H.T., Petronilho S., Villaverde J.J., Coimbra M.A., Domingues M.R.M., Ebrahimian Z.J., Silvestre A.J., Rocha S.M. Deeper insight into the monoterpenic composition of Ferula gummosa oleo-gum-resin from Iran. Industrial Crops and Products. 2012;36(1):500-507.
  18. Solouki A., Zare Mehrjerdi M., Aliniaeifard S., Azimi R. Postharvest light and temperature elicitors improve chemical composition and level of essential oils in basil (Ocimum basilicum L.) through boosting antioxidant machinery. Postharvest Biology and Technology. 2023;199:112279.
  19. Mahdi Navehsi F., Abdossi V., Abbaszadeh B., Azimi R., Dianat M. Efect of gamma rays on the essential oil and biochemical characteristics of the Satureja mutica Fisch & C. A. Mey. Scientific Reports. 2024;14:7581.
  20. Abbaszadeh B., Layeghhaghighi M., Azimi R., Hadi N. Improving water use efficiency through drought stress and using salicylic acid for proper production of Rosmarinus officinalis L. Industrial Crops and Products. 2020;144:111893.
  21. Adams R.P. Identification of Essential Oil Components by Gas Chromatography-Mass Spectroscopy, 4th Edition, Allured Publishing Corporation, Carol Stream, Illinois, 2017.
  22. Draelos Z.D. Cosmetic Dermatology: Products and Procedures. John Wiley & Sons, 2021.
  23. Garg T., Rath G., Goyal A.K. Comprehensive review on additives of topical dosage forms for drug delivery. Drug Delivery. 2015;22(8):969-987.
  24. Sekar M., Halim F.H.A. Formulation and evaluation of natural anti-acne cream containing syzygium samarangense fruits extract. Annual Research and Review in Biology. 2017;17(3):1-7.
  25. Lukic M., Pantelic I., Savic S.D. Towards optimal pH of the skin and topical formulations: from the current state of the art to tailored products. Cosmetics. 2021;8(3):69.
  26. Abbey T.C., Deak E. What's new from the CLSI subcommittee on antimicrobial susceptibility testing M100. Clinical Microbiology Newsletter. 2019;41(23):203-209.
  27. Crowther, J.M. Method for quantification of oils and sebum levels on skin using the Sebumeter. International Journal of Cosmetic Science. 2016;38(2):210-216.
  28. Blaak J., Keller D., Simon I., Schleißinger M., Schürer N.Y., Staib P. Consumer panel size in sensory cosmetic product evaluation: A pilot study from a statistical point of view.               Journal of Cosmetics, Dermatological Sciences and Applications. 2018;8(3):97-109.
  29. Segger D., Aßmus U., Brock M., Erasmy J., Finkel P., Fitzner A., Heuss H., Kortemeier U., Munke S., Rheinländer, T., Schmidt-Lewerkühne H., ‌Schneider W., Weser G. Multicenter study on measurement of the natural pH of the skin surface. International Journal of Cosmetic Science. 2008;30(1),75.
  30. Proença A.C., Luis A., Duarte A.P. The role of herbal medicine in the treatment of acne vulgaris: A systematic review of clinical trials. Evidence-Based Complementary and Alternative Medicine. 2022;(1):2011945.
  31. Kousar S., Nadeem F., Khan O., Shahzadi A. Chemical synthesis of various limonene derivatives: A comprehensive review. International Journal of Chemical and Biochemical Sciences. 2017;11:102-112.
  32. Boaro C.S.F., Vieira M.A.R., Campos F.G., Ferreira G., De-la-Cruz-Chacón I., Marques M.O.M. Factors Influencing the Production and Chemical Composition of Essential Oils in Aromatic Plants from Brazil. In: Essential Oil Research, Trends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production, Springer Nature. 2019, pp. 19-47.
  33. Eady E.A. Ingham E. Propionibacterium acnes-friend or foe? Reviews in Medical Microbiology. 1994;5(3):163-173.
  34. Claudel J.P., Auffret N., Leccia M.T., Poli F., Corvec S., Dréno B. Staphylococcus epidermidis: A potential new player in the physiopathology of acne? Dermatology. 2019;235(4):287-294.
  35. Bagatin E., Rocha M.A.D.d., Freitas T.H.P., Costa C.S. Treatment challenges in adult female acne and future directions. Expert Review of Clinical Pharmacology. 2021;14(6): 687-701.
  36. Utegenova G.A., Pallister K.B., Kushnarenko S.V., Özek G., Özek T., Abidkulova K.T., Kirpotina L.N., Schepetkin I.A., Quinn M.T., Voyich J.M. Chemical composition and antibacterial activity of essential oils from Ferula L. Species against methicillin-resistant Staphylococcus aureus. Molecules. 2018;23(7):1679.
  37. Pajohi Alamoti M., Bazargani-Gilani B., Mahmoudi R., Reale A., Pakbin B., Di Renzo T., Kaboudari A. Essential oils from indigenous Iranian plants: A natural weapon vs. multidrug-resistant Escherichia coli. Microorganisms. 2022;10(1):109.
  38. Eichenfield D.Z., Sprague J., Eichenfield L.F. Management of acne vulgaris – A Review. The Journal of the American Medical Association. 2021;326(20):2055-2067.
  39. Yang J.H., Yoon J.Y., Kwon H.H., Min S., Moon J., Suh D.H. Seeking new acne treatment from natural products, devices and synthetic drug discovery. Dermato-Endocrinology. 2017;9(1): e1356520.
  40. Ghasemi Y., Faridi P., Mehregan I., Mohagheghzadeh A. Ferula gummosa fruits: An aromatic antimicrobial agent. Chemistry of Natural Compounds. 2005;41(3):311-314.
  41. Mohammadhosseini M., Nekoei M. Chemical compositions of the essential oils and volatile compounds from the aerial parts of Ferula ovina using hydrodistillation, MAHD, SFME and HS-SPME methods. Journal of Essential Oil Bearing Plants. 2014;17(5):747-757.
  42. Li X., He C., Chen Z., Zhou C., Gan Y., Jia Y. A review of the role of sebum in the mechanism of acne pathogenesis. Journal of Cosmetic Dermatology. 2017;16(2):168-173.
  43. Talebi Kouyakhi E., Naghavi M.R., Alayhs M. Study of the essential oil variation of Ferula gummosa samples from Iran. Chemistry of Natural Compounds. 2008;44(1):124-126.
Journal of Medicinal plants and By-products
Volume 14, Issue 5
September and October 2025
Pages 489-497

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