Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine

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Document Type : Research Paper

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College of Applied Medical Sciences, University of Kerbala, 56001, Karbala, Iraq

Abstract

Green tea (Camellia sinensis) is widely consumed for its purported health benefits, yet its comprehensive effects on hematological, hepatic, and renal functions remain insufficiently characterized in animal models. This study aimed to systematically evaluate the impact of C. sinensis administration on hematological indices, liver enzyme activity, and kidney function in rabbits. Twelve healthy rabbits were randomly assigned to two groups: a control group (standard diet and water) and a treatment group receiving C. sinensis extract. Over a 60-day period, blood samples were collected at baseline and at the end of the study to assess complete blood count, liver enzymes (ALT, AST, ALP), and kidney function markers (urea, creatinine). Statistical analysis was performed using one-way ANOVA and LSD post-hoc tests. Camellia sinensis administration significantly increased white blood cell (WBC) counts (p<0.05), while red blood cell (RBC) counts remained unchanged. Notably, hemoglobin concentration and packed cell volume (PCV) were significantly reduced (p<0.05) in the treatment group. Liver enzymes (ALT, AST) and renal markers (urea, creatinine) were significantly decreased following C. sinensis supplementation, suggesting hepatoprotective and nephroprotective effects. Camellia sinensis demonstrates a dual effect by enhancing immune cell counts and improving hepatic and renal biomarkers, while potentially impairing erythropoiesis. These findings support its potential as a functional herbal medicine, warranting further mechanistic and clinical investigations.

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Journal of Medicinal plants and By-products

Articles in Press, Accepted Manuscript
Available Online from 24 June 2025

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