Document Type : Research Paper
Authors
1
Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran
2
Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3
Iranian EBM Centre: A Joanna Briggs Institute Affiliated Group, Tabriz, Iran
4
Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
5
Department of Food Hygiene, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies (AUSMT), Amol, Iran
6
St George and Sutherland Clinical School, UNSW, Sydney, Australia
7
School of Nursing and Midwifery, Alborz University of Medical Sciences, Karaj, Iran
8
Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
9
Qom University of Medical Sciences and Health Services, Qom, Iran
10
Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
Abstract
This study aimed to assess the burn healing efficacy of this traditionally used formulation (herbal ointment) in deep second-degree burns in a Florida white rabbit model. On the dorsal surface of the two rabbits, six burn wounds of the same size were inflicted. Herbal ointment was applied to the wounds on the right side, and silver sulfadiazine was applied to the wounds on the left side. On the 5th and 18th day of the treatment, the burn wound site was excised in a square shape with a narrow surrounding healthy skin for histopathological examination. At the end of day 18 of the treatment period, all the ulcers in the traditional herbal ointment group were covered entirely with epithelial tissue, while in the silver sulfadiazine group, the mean and SD of the ulcer diameter were (1.4 ± 0.1). The duration of pain, blister, and open wound in the silver sulfadiazine group was 6, 8, and 18 days; however, in the traditional herbal ointment group, on the second day, none of these complications were observed. Regarding the pathological findings, epithelial tissue renewal on day 18th was 6.63 ± 0.74 in the traditional herbal ointment group compared to 4.93 ± 0.48 in the silver sulfadiazine (P<0.05). The findings indicate that the traditional herbal ointment can reduce the duration of the wound healing process as well as the complications, including pain and blister formation. The pathological findings also suggest better epithelial tissue renewal in the traditional herbal ointment group.
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