Phytochemical and Antioxidant Evaluation of Salvia mirzayanii Extracts Prepared with Different Solvents

Mirzania, Foroogh; Ghasemi, Sara; Asgari, Zahra; Ghasemian Yadegari, Javad; Salimikia, Iraj; Adineh, Ahmad

doi:10.22034/jmpb.2025.368477.1890

Phytochemical and Antioxidant Evaluation of Salvia mirzayanii Extracts Prepared with Different Solvents

Articles in Press

Document Type : Research Paper

Authors

¹ Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

² Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6815144309, Khorramabad, Lorestan Province, Iran

³ Student Research Committee, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Lorestan Province, Iran

⁴ Department of Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran

10.22034/jmpb.2025.368477.1890

Abstract

Salvia mirzayanii is a member of the Lamiaceae family and is known to possess a wide range of pharmacological properties including antimicrobial, antioxidant, cytotoxic, anticancer, and others demonstrated during experiments conducted on this species. This plant is used for treating various ailments in Iranian traditional medicine. This research has focused on the analyzing the phenolic compounds and radical scavenging activities of hexane, acetone, and methanol extracts of Salvia mirzayanii. The antioxidant activities of these extracts were assessed using three standard methods: DPPH, FRAP, and ABTS. Among all these extracts, hexane extract showed the highest Trolox-equivalent Ferric reducing activity 12.72 ± 0.03 µmoL/g. The hexane extract also recorded the highest activity in the ABTS assay 11.86 ± 0.05. On the opposite side, the acetone extract of Salvia mirzayanii had the highest total phenolic content 71.91 ± 0.03 GAE/g, and with methanol extract put the total to 54.75 ± 0.01 mg GAE/g. In addition, Salvia mirzayanii exhibited the highest total flavonoid content 156.40 ± 0.02 mg quercetine equivalents/g. These results reveal that Salvia mirzayanii possesses potent antioxidant activities, indicating its potential usefulness in the food industry and pharmaceutical applications.

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