Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial

Document Type : Research Article

Authors

1 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

3 Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

4 Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Chronic cough often persists despite standard treatments, highlighting the need for alternative therapies. Prunus dulcis Laoq, a traditional Iranian herbal formulation, has historically been used for respiratory relief. This study evaluated its efficacy in managing treatment-resistant chronic cough. A randomized, double-blind, placebo-controlled trial was conducted with 100 participants. Patients received either Prunus dulcis Laoq or a placebo for 14 days. Symptom progression was assessed using a validated cough severity questionnaire. Data were analyzed using repeated measures ANOVA and mixed-effects models. The Laoq group showed a significant reduction in cough severity compared to placebo (F = 9.48, p = 0.03). Improvements were consistent across demographic subgroups. No adverse effects were reported, supporting the formulation’s safety. Prunus dulcis Laoq demonstrated clinical efficacy in reducing symptoms of treatment-resistant chronic cough and may serve as a safe complementary therapy. Further studies are recommended to assess its long-term effects and potential broader applications.

Keywords

Main Subjects

References

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Journal of Medicinal plants and By-products
Volume 16, Issue 1
January and February 2027
Pages 87-92

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