Protective Effects of Coriandrum sativum L. Aerial Parts and Seed Extracts Against Aluminum-Induced Hepatic and Biochemical Alterations in Rats: GC-MS Profiling and Antioxidant Evaluation

Document Type : Research Article

Authors

1 Hormozgan University, Faculty of Marine Science and Technology, Hormozgan, Iran

2 Department of Biology, Fal.C., Islamic Azad University, Isfahan, Iran

Abstract

Aluminum exposure is linked to oxidative stress and liver damage, primarily due to the excessive formation of reactive oxygen species. Accordingly, this study investigated the hepatoprotective and antioxidant effects of methanolic and ethanolic extracts, which were prepared from both the aerial parts and seeds of Coriandrum sativum L. in Wistar rats with aluminum-induced hepatotoxicity. The animals were randomly assigned to different experimental groups and received the treatments for 30 days. We evaluated the liver function indicators, lipid profile changes, antioxidant enzyme activities, DPPH radical scavenging ability, and also the expression levels of antioxidant-related genes like CAT, GPX1, and SOD2, within the same experimental protocol. Then, GC-MS analysis revealed several bioactive phytochemicals with reported antioxidant potential. After aluminum administration, the liver enzyme levels increased significantly, and the oxidative stress markers were significantly elevated, while antioxidant gene expression decreased significantly. Treatment with Coriandrum sativum L. extracts improved the biochemical and antioxidant parameters significantly compared to the aluminum-treated group (P<0.05), particularly in the methanolic seed extracts. These results suggest that Coriandrum sativum L. has antioxidant and hepatoprotective properties, which may help attenuate aluminum induced liver injury.

Keywords

Main Subjects

References

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Journal of Medicinal Plants and By-products
Volume 16, Issue 2
March and April 2027
Pages 175-189

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